tailieunhanh - Báo cáo y học: " Does a new polyomavirus contribute to Merkel cell carcinoma"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Critical Care giúp cho các bạn có thêm kiến thức về ngành y học đề tài: Does a new polyomavirus contribute to Merkel cell carcinoma? | Minireview Does a new polyomavirus contribute to Merkel cell carcinoma Kelly M Garneski James A DeCaprio and Paul Nghiem 4 Addresses Departments of Medicine Dermatology and Pathology University of Washington Seattle WA 98109 USA. Department of Medical Oncology Dana-Farber Cancer Institute and Department of Medicine Brigham and Women s Hospital and Harvard University Boston MA 02115 USA. Clinical Research Division Fred Hutchinson Cancer Research Center Seattle WA 98109 USA. Correspondence Paul Nghiem. Email pnghiem@ Published 17 June 2008 Genome Biology 2008 9 228 doi gb-2008-9-6-228 The electronic version of this article is the complete one and can be found online at http 2008 9 6 228 2008 BioMed Central Ltd Abstract A new technique designed to hunt for non-human transcripts has identified a novel SV40-like virus present in the majority of Merkel cell carcinomas. Here we examine what it will take to determine whether or not this virus contributes to carcinogenesis. Merkel cell carcinoma MCC is an uncommon and aggressive skin cancer. More than one-third of MCC patients will die from this cancer making it twice as lethal as malignant melanoma 1 . The reported incidence of MCC has tripled over the past 20 years because of improved detection and a rise in the number of elderly and immunosuppressed individuals who are at risk 2 . It is estimated that there will be 1 500 new cases of MCC this year in the United States 3 . There has been a long-standing interest in the etiology of MCC. Several lines of evidence suggest a strong link between MCC and ultraviolet light exposure. For example the incidence of MCC is higher at more equatorial latitudes 4 81 of primary tumors occur on sun-exposed skin 1 and Caucasians have the greatest risk. MCC incidence is also strongly coupled with advanced age indeed 90 of people diagnosed with MCC are over the age of 50 1 . Importantly there is a striking epidemiologic association between .