tailieunhanh - Báo cáo y học: "What makes pathogens pathogenic"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Critical Care giúp cho các bạn có thêm kiến thức về ngành y học đề tài: What makes pathogens pathogenic. | Review What makes pathogens pathogenic Garth D Ehrlich N Luisa Hiller and Fen Ze Hu Addresses Center for Genomic Sciences Allegheny General Hospital Allegheny Singer Research Institute 320 E. North Ave Pittsburgh PA 15212 USA. Department of Microbiology and Immunology Drexel University College of Medicine Allegheny Campus 320 E. North Ave Pittsburgh PA 15212 USA. Correspondence Garth D Ehrlich. Email gehrlich@ Published 24 June 2008 Genome Biology 2008 9 225 doi gb-2008-9-6-225 The electronic version of this article is the complete one and can be found online at http 2008 9 6 225 2008 BioMed Central Ltd Abstract Metazoans contain multiple complex microbial ecosystems in which the balance between host and microbe can be tipped from commensalism to pathogenicity. This transition is likely to depend both on the prevailing environmental conditions and on specific gene-gene interactions placed within the context of the entire ecosystem. Metazoans and higher plants are not single-species organisms but are complex ecosystems composed of a multicellular eukaryotic host with its unique genetic complement 1 and a multitude of microbiomes . Each microbiome is composed of multiple prokaryotic and eukaryotic symbionts and the microbiomes and the host collectively make up the symbiome Table 1 2 . Symbiotic relationships within these ecosystems exist between each of the microbial strains and the host and also between and among the members of each microbiome. These interdependencies run the gamut from mutualism in which both or all species benefit to commensalism where one party benefits and does no appreciable harm to the others to parasitism where one of the species benefits at the expense of the other s . Finally a pathogenic relationship exists if the parasite produces a morbid condition in the host. These divisions are themselves an oversimplification of what is in all likelihood a continuum where a given strain of microorganism falls within