tailieunhanh - Báo cáo y học: " Organization of the pronephric kidney revealed by large-scale gene expression mapping"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Critical Care giúp cho các bạn có thêm kiến thức về ngành y học đề tài: Organization of the pronephric kidney revealed by large-scale gene expression mapping. | Open Access Organization of the pronephric kidney revealed by large-scale gene expression mapping Daniela Raciti Luca Reggiani Lars Geffers Qiuhong Jiang Francesca Bacchion Astrid E Subrizi Dave Clements Christopher Tindal Duncan R Davidson Brigitte Kaissling and André W Brandli Addresses institute of Pharmaceutical Sciences Department of Chemistry and Applied Biosciences ETH Zurich Wolfgang-Pauli-Strasse 10 CH-8093 Zurich Switzerland. Department of Genes and Behavior Max Planck Institute for Biophysical Chemistry Am Fassberg 11 D-37077 Gottingen Germany. MRC Human Genetics Unit Western General Hospital Crewe Road Edinburgh EH4 2XU UK. institute of Anatomy University of Zurich Winterthurerstrasse 190 CH-8057 Zurich Switzerland. Correspondence André W Brandli. Email brandli@ Published 20 May 2008 Genome Biology 2008 9 R84 doi 186 gb-2008-9-5-r84 The electronic version of this article is the complete one and can be found online at http 2008 9 5 R84 Received 11 January 2008 Revised 19 March 2008 Accepted 20 May 2008 2008 Raciti et al. licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background The pronephros the simplest form of a vertebrate excretory organ has recently become an important model of vertebrate kidney organogenesis. Here we elucidated the nephron organization of the Xenopus pronephros and determined the similarities in segmentation with the metanephros the adult kidney of mammals. Results We performed large-scale gene expression mapping of terminal differentiation markers to identify gene expression patterns that define distinct domains of the pronephric kidney. We analyzed the expression of over 240 genes which included members of the solute carrier claudin and .