tailieunhanh - Báo cáo y học: "A rational approach to cancer therapy"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Critical Care giúp cho các bạn có thêm kiến thức về ngành y học đề tài: A rational approach to cancer therapy. | Meeting report A rational approach to cancer therapy Kylie L Gorringe and Ian G Campbell Addresses VBCRC Cancer Genetics Laboratory Peter MacCallum Cancer Centre East Melbourne Victoria 3002 Australia. Department of Pathology University of Melbourne Melbourne Victoria 8006 Australia. Correspondence Ian G Campbell. Email Published 7 May 2008 Genome Biology 2008 9 306 doi gb-2008-9-5-306 The electronic version of this article is the complete one and can be found online at http 2008 9 5 306 2008 BioMed Central Ltd A report on the 20th Annual Lorne Cancer Conference Lorne Australia 14-16 February 2008. Targeted molecular therapy for cancer is becoming a holy grail for researchers. The identification and characterization of cancer genes is the first step towards developing such therapeutics and high-throughput technologies are increasingly being used to identify these genes elucidate their function and identify potential drug molecules that target them. At all levels of this process a deep understanding of the molecular pathways involved is crucial to the successful development of a new therapeutic. In particular combinations of therapies that each target aspects of the same or interacting pathways offer possibilities for synergy reducing overall drug exposure and side effects for the patient. These themes were well covered at this years s Lorne cancer conference. High-throughput technologies The impact of high-throughput technologies on cancer research was electrifyingly demonstrated by Mike Stratton Wellcome Trust Sanger Centre Cambridge UK who showed how next generation massively parallel sequencing technologies can be used to determine the fine structure of chromosomal rearrangements. He described published work on the identification of rearrangement breakpoints in cancer cells. This involved the sequencing of large numbers of bacterial artificial chromosome clones with mismatched end sequences each clone .