tailieunhanh - Báo cáo y học: "Porin new light onto chromatin and nuclear organization"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Critical Care giúp cho các bạn có thêm kiến thức về ngành y học đề tài:Porin new light onto chromatin and nuclear organization. | Minireview Porin new light onto chromatin and nuclear organization Lee E Finlan and Wendy A Bickmore Address MRC Human Genetics Unit Institute of Genetics and Molecular Medicine University of Edinburgh Crewe Road Edinburgh EH4 2XU UK. Correspondence Lee E Finlan. Email lfinlan@ Wendy A Bickmore Email. Published 16 May 2008 Genome Biology 2008 9 222 doi gb-2008-9-5-222 The electronic version of this article is the complete one and can be found online at http 2008 9 5 222 2008 BioMed Central Ltd Abstract A recent report identifies sites in the human genome that can associate with nucleoporin 93 a subunit of the nuclear pore complex. These associations are modulated by levels of global histone acetylation and highlight the dynamic nature of chromatin organization in the nucleus. Nuclear pore complexes NPCs in the nuclear envelope mediate the selective exchange of macromolecules into and out of the nucleus by facilitated diffusion. The NPC is composed of multiple copies of roughly 30 distinct nucleoporins 1-3 and its structure is conserved throughout eukaryotes. Although numerous studies have examined how nucleoporins function in nucleo-cytoplasmic transport relatively little attention has been paid to any role they might have in influencing genome organization in mammalian cells. The nuclear periphery has customarily been associated with inactive chromatin structure and with the repression of gene expression 4-7 . Evidence for a more complex relationship between gene activity and the nuclear periphery linking the upregulation of gene expression with the association of chromatin with the NPC came initially from studies in budding yeast Saccharomyces cerevisiae and Drosophila 8 9 . Now a recent report in Genes Development from Pamela Silver and her colleagues Brown et al. 10 shows by chromatin immunoprecipitation ChIP that physical associations between the nucleoporin NUP93 and specific regions of human .