tailieunhanh - Báo cáo y học: "Natural selection of protein structural and functional properties: a single nucleotide polymorphism perspect"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Critical Care giúp cho các bạn có thêm kiến thức về ngành y học đề tài: Natural selection of protein structural and functional properties: a single nucleotide polymorphism perspective. | Research Open Access Natural selection of protein structural and functional properties a single nucleotide polymorphism perspective Jinfeng Liu Yan Zhang Xingye Lef and Zemin Zhang Addresses Department of Bioinformatics Genentech Inc. 1 DNA Way South San Francisco CA 94080 USA. Department of Biostatistics Genentech Inc. 1 DNA Way South San Francisco CA 94080 USA. Correspondence Zemin Zhang. Email zemin@ Published 8 April 2008 Genome Biology 2008 9 R69 doi 186 gb-2008-9-4-r69 The electronic version of this article is the complete one and can be found online at http 2008 9 4 R69 Received 20 March 2008 Revised 25 March 2008 Accepted 8 April 2008 2008 Liu et al. licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background The rates of molecular evolution for protein-coding genes depend on the stringency of functional or structural constraints. The Ka Ks ratio has been commonly used as an indicator of selective constraints and is typically calculated from interspecies alignments. Recent accumulation of single nucleotide polymorphism SNP data has enabled the derivation of Ka Ks ratios for polymorphism SNP A S ratios . Results Using data from the dbSNP database we conducted the first large-scale survey of SNP A S ratios for different structural and functional properties. We confirmed that the SNP A S ratio is largely correlated with Ka Ks for divergence. We observed stronger selective constraints for proteins that have high mRNA expression levels or broad expression patterns have no paralogs arose earlier in evolution have natively disordered regions are located in cytoplasm and nucleus or are related to human diseases. On the residue level we found higher degrees of variation for residues .