tailieunhanh - Báo cáo y học: " ModuleMiner - improved computational detection of cis-regulatory modules: are there different modes of gene regulation in embryonic development and adult tissues"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Critical Care giúp cho các bạn có thêm kiến thức về ngành y học đề tài: ModuleMiner - improved computational detection of cis-regulatory modules: are there different modes of gene regulation in embryonic development and adult tissues? | Open Access ModuleMiner - improved computational detection of cis-regulatory modules are there different modes of gene regulation in embryonic development and adult tissues Peter Van Loo Stein Aerts Bernard Thienpont Bart De Moor Yves Moreau and Peter Marynen Addresses Department of Molecular and Developmental Genetics VIB Herestraat 49 B-3000 Leuven Belgium. Department of Human Genetics University of Leuven Herestraat 49 B-3000 Leuven Belgium. Bioinformatics group Department of Electrical Engineering ESAT-SCD University of Leuven Kasteelpark Arenberg B-3001 Heverlee Belgium. Correspondence Peter Van Loo. Email Published 7 April 2008 Genome Biology 2008 9 R66 doi 186 gb-2008-9-4-r66 The electronic version of this article is the complete one and can be found online at http 2008 9 4 R66 Received 30 December 2007 Revised 7 March 2008 Accepted 7 April 2008 2008 Van Loo et al. licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract We present ModuleMiner a novel algorithm for computationally detecting ás-regulatory modules CRMs in a set of co-expressed genes. ModuleMiner outperforms other methods for CRM detection on benchmark data and successfully detects CRMs in tissue-specific microarray clusters and in embryonic development gene sets. Interestingly CRM predictions for differentiated tissues exhibit strong enrichment close to the transcription start site whereas CRM predictions for embryonic development gene sets are depleted in this region. Background The identification and functional annotation of transcriptional regulatory sequences in the human genome is lagging far behind the rapidly increasing knowledge of proteinencoding genes. These transcriptional regulatory .