tailieunhanh - Báo cáo y học: "Chromatin organization and expression"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Critical Care giúp cho các bạn có thêm kiến thức về ngành y học đề tài: Chromatin organization and expression. | Meeting report Chromatin organization and expression Elaine Sanij and Ross D Hannan Addresses Division of Research Peter MacCallum Cancer Centre St Andrews Place East Melbourne 3002 Victoria Australia. Department of Biochemistry and Molecular Biology University of Melbourne Parkville 3010 Victoria Australia. Correspondence Ross D Hannan. Email Published 14 April 2008 Genome Biology 2008 9 305 doi gb-2008-9-4-305 The electronic version of this article is the complete one and can be found online at http 2008 9 4 305 2008 BioMed Central Ltd A report on the 29th Lorne Genome Conference on the Organization and Expression of the Genome Lorne Australia 17-21 February 2008. The Lorne Genome conference is held annually in the historic seaside town of Lorne on the southern Australian coast. This year s meeting showcased a broad range of topics including chromatin structure epigenetic memory transcriptional regulation and the role of noncoding small RNAs in gene silencing. Here we report on some of the highlights of the meeting. Chromatin dynamics and transcription regulation There is now strong evidence for the role of noncoding RNA particularly microRNA miRNA in establishing and maintaining the transcriptional state of the chromatin. Michael Axtell Pennsylvania State University University Park USA described new molecular and computational biology techniques to screen for novel small RNAs and their functions in plants. He and his colleagues applied high-throughput degradome sequencing and directly identified miRNA targets using experimental data. In addition they recognized molecular functions for several other types of small RNAs in various plant species. Interestingly they showed that diverse miRNA sequences from different plant species can perform common biological functions. Posttranslational modifications of histones form the histone code that modulates transcription by affecting histone-DNA interactions and recruiting