tailieunhanh - Báo cáo y học: " Cell signaling and cancer"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Critical Care giúp cho các bạn có thêm kiến thức về ngành y học đề tài: Cell signaling and cancer. | Meeting report Cell signaling and cancer Eleni Bazigou and Charalampos Rallis Addresses Lymphatic Development Laboratory and Developmental Genetics Laboratory London Research Institute Cancer Research UK Lincoln s Inn Fields London WC2A 3PX UK. Correspondence Charalampos Rallis. Email Published 23 July 2007 Genome Biology 2007 8 310 doi gb-2007-8-7-3l0 The electronic version of this article is the complete one and can be found online at http 2007 8 7 310 2007 BioMed Central Ltd A report on the Cancer Research UK London Research Institute Special Conference Signal Transduction London UK 14-16 May 2007. Disruption of intracellular signaling is central to many different diseases including cancer. A conference on signaling mechanisms held recently in London under the auspices of the charity Cancer Research UK looked at cell-signaling pathways in relation to cancer and how they may point to new therapeutic approaches. Signaling pathways and signaling mechanisms The canonical Wnt P-catenin pathway is implicated in both normal development and disease. For example APC a component of the canonical Wnt signaling pathway was first isolated as a tumor suppressor gene in human colon cancer and activating mutations in P-catenin are found in human colon cancer and melanomas. Two distinct receptors are required for its activation Frizzled a seven-span receptor and the LDL-receptor related proteins 5 or 6 LRP5 or LRP6 . Xi He Children s Hospital and Harvard Medical School Boston USA discussed the formation and activation of the Frizzled-LRP5 6 receptor complex. Upon binding to Wnt ligands LRP6 is phosphorylated on serines S in multiple proline P -rich PPPSPxS motifs which is sufficient to activate the pathway. He went on to describe how the two serines in PPPSPxS are phosphorylated by two distinct kinases casein kinase 1 and glycogen synthase kinase 3 Gsk3P . A role for Gsk3P in the activation of the pathway was something .