tailieunhanh - Báo cáo y học: "Drosophila by the dozen"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Critical Care giúp cho các bạn có thêm kiến thức về ngành y học đề tài: Drosophila by the dozen. | Meeting report Drosophila by the dozen Susan E Celniker and Roger A Hoskins Address Berkeley Drosophila Genome Project Life Sciences Division Lawrence Berkeley National Laboratory 1 Cyclotron Road Berkeley CA 94720 USA. Correspondence Susan Celniker. Email celniker@ Published 13 July 2007 Genome Biology 2007 8 309 doi gb-2007-8-7-309 The electronic version of this article is the complete one and can be found online at http 2007 8 7 309 2007 BioMed Central Ltd A report of the 48th Annual Drosophila Research Conference Philadelphia USA 7-11 March 2007. This year s conference on Drosophila research illustrated well the current focus of Drosophila genomics on the comprehensive identification of functional elements in the genome sequence including mRNA transcripts arising from multiple alternative start sites and splice sites a multiplicity of noncoding transcripts and small RNAs identification of binding sites for transcription factors sequence conservation in related species and sequence variation within species. Resources and technologies for genetics and functional genomics are steadily being improved including the building of collections of transposon insertion mutants and hairpin constructs for RNA interference RNAi . The conference also highlighted progress in the use of genomic information by many laboratories to study diverse aspects of biology and models of human disease. Here we will review a few highlights of especial interest to readers of Genome Biology. Comparative genomic analysis The largest new Drosophila dataset comes from the draft genomic sequencing of 11 sibling species of D. melanogaster with phylogenetic relationships spanning 40-60 million years. Michael Eisen Lawrence Berkeley National Laboratory Berkeley USA presented a comparative analysis of these new genomic sequences with a focus on the evolution of gene regulation. Whole-genome shotgun sequences and assemblies for Drosophila simulans D. sechellia D. .