tailieunhanh - Báo cáo khoa học: " Partial direct contact transmission in ferrets of a mallard H7N3 influenza virus with typical avian-like receptor specificity"

Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài: Partial direct contact transmission in ferrets of a mallard H7N3 influenza virus with typical avian-like receptor specificity | Virology Journal BioMed Central Open Access Partial direct contact transmission in ferrets of a mallard H7N3 influenza virus with typical avian-like receptor specificity Haichen Song1 2 Hongquan Wan1 3 Yonas Araya1 and Daniel R Perez 1 Address Department of Veterinary Medicine University of Maryland College Park and Virginia-Maryland Regional College of Veterinary Medicine 8075 Greenmead Drive College Park MD 20742 USA 2Synbiotics Corporation 8075 Greenmead Drive College Park MD 20742 USA and 3Influenza Division Centers for Disease Control and Prevention 1600 Clifton Road Atlanta GA 30333 USA Email Haichen Song - songhc@ Hongquan Wan - gvd2@ Yonas Araya - yoni@ Daniel R Perez - dperez1@ Corresponding author Published 14 August 2009 Received 27 July 2009 Accepted 14 August 2009 Virology Journal 2009 6 126 doi 1743-422X-6-126 This article is available from http content 6 1 126 2009 Song et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background Avian influenza viruses of the H7 subtype have caused multiple outbreaks in domestic poultry and represent a significant threat to public health due to their propensity to occasionally transmit directly from birds to humans. In order to better understand the cross species transmission potential of H7 viruses in nature we performed biological and molecular characterizations of an H7N3 virus isolated from mallards in Canada in 2001. Results Sequence analysis that the HA gene of the mallard H7N3 virus shares 97 identity with the highly pathogenic avian influenza HPAI H7N3 virus isolated from a human case in British Columbia Canada in 2004. The mallard H7N3 virus was able to replicate in quail and chickens and transmitted