tailieunhanh - Báo cáo khoa học: " Hepatitis C Virus entry: the early steps in the viral replication cycle"

Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài: Hepatitis C Virus entry: the early steps in the viral replication cycle | Virology Journal BioMed Central Open Access Hepatitis C Virus entry the early steps in the viral replication cycle Ali Sabahi Address Department of Microbiology and Immunology Tulane University Health Sciences Center New Orleans Louisiana USA Email Ali Sabahi - asabahi@ Published 30 July 2009 Received 7 July 2009 Accepted 30 July 2009 Virology Journal 2009 6 117 doi 1743-422X-6-117 This article is available from http content 6 1 1 17 2009 Sabahi licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Approximately 170 million are infected with the hepatitis C virus HCV world wide and an estimated million are HCV RNA positive in the United States alone. The acute phase of the HCV infection in majority of individuals is asymptomatic. A large percentage of those infected with HCV are unable to clear the virus and become chronically infected. The study of the HCV replication cycle was hampered due to difficulties in growing and propagating the virus in an in vitro setting. The advent of the HCV pseudo particle HCVpp and HCV cell culture HCVcc systems have made possible the study of the HCV replication cycle in vitro. Studies utilizing the HCVpp and HCVcc systems have increased our insight into the early steps of the viral replication cycle of HCV such as the identification of cellular co-receptors for binding and entry. The aim of this article is to provide a review of the outstanding literature on HCV entry specifically looking at cellular coreceptors involved and putting the data in the context of the systems used purified viral envelope proteins HCVpp system HCVcc system and or patient sera and to also give a brief description of the cellular co-receptors themselves. Introduction .