tailieunhanh - Báo cáo khoa học: " 9-aminoacridine Inhibition of HIV-1 Tat Dependent Transcription"

Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài: 9-aminoacridine Inhibition of HIV-1 Tat Dependent Transcription | Virology Journal BioMed Central Research 9-aminoacridine Inhibition of HIV-1 Tat Dependent Transcription Irene Guendel1 Lawrence Carpio1 Rebecca Easley1 Rachel Van Duyne1 William Coley1 Emmanuel Agbottah1 Cynthia Dowd2 Fatah Kashanchi1 and Kylene Kehn-Hall 1 Address The George Washington University Department of Microbiology Immunology and Tropical Medicine 2300 I Street NW Washington DC 20037 USA and 2The George Washington University Department of Chemistry Washington DC 20037 USA Email Irene Guendel - mtmixg@ Lawrence Carpio - Rebecca Easley - rleasle@ Rachel Van Duyne - bcmrvv@ William Coley-mtmwdc@ Emmanuel Agbottah - bcmeta@ Cynthia Dowd - cdowd@ Fatah Kashanchi - bcmfxk@ Kylene Kehn-Hall - bcmkwk@ Corresponding author Open Access Published 24 July 2009 Received 11 June 2009 Virology Journal 2009 6 114 doi 1743-422X-6-114 Accepted 24 July 2009 This article is available from http content 6 1 1 14 2009 Guendel et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract As part of a continued search for more efficient anti-HIV-1 drugs we are focusing on the possibility that small molecules could efficiently inhibit HIV-1 replication through the restoration of p53 and p21WAF1 functions which are inactivated by HIV-1 infection. Here we describe the molecular mechanism of 9-aminoacridine 9AA mediated HIV-1 inhibition. 9AA treatment resulted in inhibition of HIV LTR transcription in a specific manner that was highly dependent on the presence and location of the amino moiety. Importantly virus replication was found to be inhibited .