tailieunhanh - Báo cáo y học: "Multiple-center evaluation of mortality associated with acute kidney injury in critically ill patients: a competing risks analysis"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Critical Care giúp cho các bạn có thêm kiến thức về ngành y học đề tài: Multiple-center evaluation of mortality associated with acute kidney injury in critically ill patients: a competing risks analysis. | Clec h et al. Critical Care 2011 15 R128 http content 15 3 R128 KS CRITICAL CARE RESEARCH Open Access Multiple-center evaluation of mortality associated with acute kidney injury in critically ill patients a competing risks analysis 1 3 2 24 Christophe Clech 1 Frédéric Gonzalez Alexandre Lautrette Molière Nguile-Makao Malte Garrouste-Orgeas c m I f I I I5 k-. I r I o 4 s 6 A 4 k I rA r r r V k r -X r I o 7 c K S f 4 m I I I 1 D r 4 r r r I_I- k-v k i 4 f- r D 8 Samir Jamali Dany Golgran-ioledano Adrien uescorps-ueclere Frank Chemouni Rebecca Hamidfar-Roy Elie Azoulay2 9 and Jean-Frangois Timsit2 8 Abstract Introduction In this study we aimed to assess the association between acute kidney injury AKI and mortality in critically ill patients using an original competing risks approach. Methods Unselected patients admitted between 1997 and 2009 to 13 French medical or surgical intensive care units were included in this observational cohort study. AKI was defined according to the RIFLE criteria. The following data were recorded baseline characteristics daily serum creatinine level daily Sequential Organ Failure Assessment SOFA score vital status at hospital discharge and length of hospital stay. Patients were classified according to the maximum RIFLE class reached during their ICU stay. The association of AKI with hospital mortality with discharge alive considered as a competing event was assessed according to the Fine and Gray model. Results Of the 8 639 study patients had AKI of whom received renal replacement therapy. Patients with AKI had higher crude mortality rates and longer lengths of hospital stay than patients without AKI. In the Fine and Gray model independent risk factors for hospital mortality were the RIFLE classes Risk sub-hazard ratio SnR and 95 confidence interval 95 CI to P Injury SHR and 95 CI to P and Failure SHR and 95 CI to P nonrenal SOFA score SHR per .

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