tailieunhanh - Báo cáo khoa học: " Pathological studies on postvaccinal reactions of Rift Valley fever in goats"

Pathological studies on postvaccinal reactions of Rift Valley fever in goats | Virology Journal BioMed Central Research Pathological studies on postvaccinal reactions of Rift Valley fever in goats Samia Ahmed Kamal Open Access Address Animal Health Research Institute Dokki Giza Egypt Email Samia Ahmed Kamal - selkabany@ Published 6 July 2009 Received 23 April 2009 Virology Journal 2009 6 94 doi 1743-422X-6-94 Accepted 6 July 2009 This article is available from http content 6 1 94 2009 Kamal licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract RVF live attenuated vaccine Smithburn strain was evaluated by using goats as experimental animal. The results indicate that this vaccine cause severe deleterious pathological changes in liver especially in kids and causing abortion in pregnant does. The virus was seen to be propagated inside hepatic cells forming intranuclear inclusions which was also seen by . Viral antigens were detected in hepatic cells gall bladder endothelial lining of blood vessels leukocytes kidneys and heart by using immunoflourescent technique. It could be concluded that the use of live attenuated vaccine of RVF Smithburn strain for immunization of live stock is not safe in Egypt as it considered an endemic area. Introduction Rift Valley Fever RVF is a febrile disease that affected livestock and humans transmitted by mosquitoes and caused by a virus genus Phlebovirus family Bunyaviri-dae that can persist in nature 1 . The virus was first isolated in Kenya in 1930 2 . Until 1977 Rift Valley Fever disease was geographically limited to Africa and then it was recorded for the first time in Egypt as an epizootic 3 . The Rift Valley Fever virus is a single stranded RNA with three segments S M and L each segment is enclosed in a separate nucleocapsid .