tailieunhanh - Báo cáo khoa học: " Expression of Human CD4 and chemokine receptors in cotton rat cells confers permissiveness for productive HIV infection"

Tham khảo luận văn - đề án 'báo cáo khoa học: " expression of human cd4 and chemokine receptors in cotton rat cells confers permissiveness for productive hiv infection"', luận văn - báo cáo phục vụ nhu cầu học tập, nghiên cứu và làm việc hiệu quả | Virology Journal BioMed Central Research Expression of Human CD4 and chemokine receptors in cotton rat cells confers permissiveness for productive HIV infection Jorge CG Blanco 1 LioubovM Pletneva1 Lindsay Wieczorek2 Dimple Khetawat3 Tzanko S Stantchev3 Christopher C Broder3 Victoria R Polonis2 and Gregory A Prince1 Open Access Address 1Virion Systems Inc. 9610 Medical Center Drive Suite 100 Rockville Maryland 20850 USA 2The United State Military HIV Research Program Rockville Maryland 20850 USA and 3Department of Microbiology and Immunology Uniformed Services University of the Health Sciences Bethesda Maryland 20814 USA Email Jorge CG Blanco - jblanco@ Lioubov M Pletneva - lubapletneva@ Lindsay Wieczorek - lwieczorek@ Dimple Khetawat - dkhetawat@ Tzanko S Stantchev - tstantchev@ Christopher C Broder - cbroder@ Victoria R Polonis - vpolonis@ Gregory A Prince - gprince@ Corresponding author Published 14 May 2009 Received 4 May 2009 Accepted 14 May 2009 Virology Journal 2009 6 57 doi l 743-422X-6-57 This article is available from http content 6 1 57 2009 Blanco et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background Current small animal models for studying HIV-1 infection are very limited and this continues to be a major obstacle for studying HIV-1 infection and pathogenesis as well as for the urgent development and evaluation of effective anti-HIV-1 therapies and vaccines. Previously it was shown that HIV-1 can infect cotton rats as indicated by development of antibodies against all major proteins of the virus the detection of viral cDNA in spleen and brain of challenged animals the