tailieunhanh - Báo cáo y học: " Age of red blood cells and mortality in the critically ill"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Critical Care giúp cho các bạn có thêm kiến thức về ngành y học đề tài: Age of red blood cells and mortality in the critically ill. | Pettilă et al. Critical Care 2011 15 R116 http content 15 2 R116 KS CRITICAL CARE RESEARCH Open Access Age of red blood cells and mortality in the critically ill Villo Po-f-f-iIs 1 A ndrciXM I A ocf hí mmL 1 Ạ Iic1 2ir IP i liwkiml 1 2 Í Iif kì2ol I Railox 1 K l A mmH3 4 Pillion Px rcic1 Ville rettild Andiew J vvestbiook Alistdii D Niciiol Micildel J Bdiley Eiicd M WWU Gillidn syies I m lico p p H Ỉ 11 Ỉ r tc4 A I i cr if i Pfroot 5 Pro fir hl6 I x nnoffo I I irr3 1 Moil CArfAirr l7 p C rìhTimTirM8 Louise E Phillips Alison Stieet Cidig rieiicii Lyinieiie Muiidy Neil Oifoid JOHN D Sdiudmdiid Rindldo Bellomo1 did Ddvid J Cooper1 2 for the Blood Obseivdtiondl Study Investigdtois foi the ANZICS Clinicdl Tiidls Gioup Abstract Introduction In ciiticdlly ill pdtients it is uncertain whethei exposure to oldei red blood cells RBCs mdy contribute to mortality. We therefore dimed to evdludte the dssocidtion between the dge of RBCs dnd outcome in d ldige unselected cohort of ciiticdlly ill pdtients in Australis dnd New Zedldnd. We hypothesized thdt exposure to even d single unit of oldei RBCs mdy be dssocidted with dn inciedsed iisk of dedth. Methods We conducted d prospective multicentei obseivdtiondl study in 47 ICUs duiing d 5-week period between August 2008 dnd Septembei 2008. We included 757 ciiticdlly ill ddult pdtients receiving dt ledst one unit of RBCs. To test oui hypothesis we compdied hospitdl moitdlity dccoiding to quditiles of exposure to mdximum dge of RBCs without dnd with ddjustment foi possible confounding fdctois. Results Compdied with othei quditiles medn mdximum ied cell dge ddys mortality 121 568 pdtients tiedted with exposure to the lowest quditile of oldest RBCs medn mdximum ied cell dge ddys hospitdl moitdlity 25 189 hdd dn unddjusted dbsolute risk reduction in hospitdl moitdlity of 95 confidence inteivdl to . Aftei ddjustment foi Acute Physiology dnd Chionic Hedlth Evdludtion III scoie othei blood component