tailieunhanh - Báo cáo khoa học: " Highly quantitative serological detection of anti-cytomegalovirus (CMV) antibodies"

Highly quantitative serological detection of anti-cytomegalovirus (CMV) antibodies | Virology Journal BioMed Central Open Access Highly quantitative serological detection of anti-cytomegalovirus CMV antibodies Peter D Burbelo 1 Alexandra T Issa1 Kathryn H Ching1 Maurice Exner2 W Lawrence Drew3 Harvey J Alter4 and Michael J Iadarola1 Address 1Neurobiology and Pain Therapeutics Section Laboratory of Sensory Biology National Institute of Dental and Craniofacial Research National Institutes of Health Bethesda Maryland 20892 USA 2Focus Diagnostics Inc Cypress California 90630-4717 USA 3University of California San Francisco UCSF Medical Center at Mount Zion San Francisco California 94115 USA and 4Infectious Disease Section Department of Transfusion Medicine NIH Clinical Center National Institutes of Health Bethesda Maryland 20892 USA Email Peter D Burbelo - burbelop@ AlexandraT Issa - Issaa@ Kathryn H Ching - ChingK@ Maurice Exner - mexner@ W Lawrence Drew - Harvey J Alter - halter@ Michael J Iadarola - iadarola@ Corresponding author Published I May 2009 Received 13 February 2009 Accepted 1 May 2009 Virology journal 2009 6 45 doi 1743-422X-6-45 This article is available from http content 6 1 45 2009 Burbelo et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background Human cytomegalovirus infection is associated with a variety of pathological conditions including retinitis pneumonia hepatitis and encephalitis that may be transmitted congenitally horizontally and parenterally and occurs both as a primary infection and as reactivation in immunocompromised individuals. Currently there is a need for improved quantitative serological tests to document seropositivity with high .