tailieunhanh - Báo cáo y học: "Common NFKBIL2 polymorphisms and susceptibility to pneumococcal disease: a genetic association study"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Critical Care giúp cho các bạn có thêm kiến thức về ngành y học đề tài: Common NFKBIL2 polymorphisms and susceptibility to pneumococcal disease: a genetic association study. | Chapman et al. Critical Care 2010 14 R227 http content 14 6 R227 KS CRITICAL CARE RESEARCH Open Access Common NFKBIL2 polymorphisms and susceptibility to pneumococcal disease a genetic association study 1 1 6 Stephen J Chapman 1 Chiea C Khor1 Fredrik O Vannberg Anna Rautanen Andrew Walley 1 Shelley Segal 2frir R K ir tr tro1 7 DmKarf IO nm icic3 n rÌTỉx 7 Mnrhort Dochi 18 rhcirri - A r rrxrxlx9 A RarHow8 canin E Mooie RObeiL JO Davies Nicholas P Day iNOiben resiiu Deiiick W Ciook James A Deikley Thomas N Williams6 8 9 10 11 J Anthony Scott8 Adrian VS Hill1 Abstract Introduction Streptococcus pneumoniae remains a major global health problem and a leading cause of death in children worldwide. The factors that influence development of pneumococcal sepsis remain poorly understood although increasing evidence points towards a role for genetic variation in the host s immune response. Recent insights from the study of animal models rare human primary immunodeficiency states and population-based genetic epidemiology have focused attention on the role of the proinflammatory transcription factor NF-kD in pneumococcal disease pathogenesis. The possible role of genetic variation in the atypical NF-kD inhibitor IkD-R encoded by NFKBIL2 in susceptibility to invasive pneumococcal disease has not to our knowledge previously been reported upon. Methods An association study was performed examining the frequencies of nine common NFKBIL2 polymorphisms in two invasive pneumococcal disease case-control groups European individuals from hospitals in Oxfordshire UK 275 patients and 733 controls and African individuals from Kilifi District Hospital Kenya 687 patients with bacteraemia of which 173 patients had pneumococcal disease together with 550 controls . Results Five polymorphisms significantly associated with invasive pneumococcal disease susceptibility in the European study of which two polymorphisms also associated with disease in African individuals. .