tailieunhanh - Báo cáo y học: "Comparative analysis between a low pathogenic and a high pathogenic influenza H5 hemagglutinin in cell entry"

Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài: Comparative analysis between a low pathogenic and a high pathogenic influenza H5 hemagglutinin in cell entry | Virology Journal BioMed Central Open Access Short report Comparative analysis between a low pathogenic and a high pathogenic influenza H5 hemagglutinin in cell entry Emily Rumschlag-Booms1 Ying Guo1 2 Jizhen Wang1 Michael Caffrey3 and Lijun Rong 1 Address Department of Microbiology and Immunology College of Medicine University of Illinois at Chicago Chicago Illinois 60612 USA institute of Materia Medica Peking Union Medical College and Chinese Academy of Medical Sciences Beijing 100050 PR China and 3Department of Biochemistry and Molecular Genetics College of Medicine University of Illinois at Chicago Chicago Illinois 60607 USA Email Emily Rumschlag-Booms - Ying Guo - yingguo6@ Jizhen Wang - jwang27@ Michael Caffrey-caffrey@ Lijun Rong - lijun@ Corresponding author Published 10 June 2009 Received 29 April 2009 Accepted 10 June 2009 Virology journal 2009 6 76 doi 186 1743-422X-6-76 This article is available from http content 6 1 76 2009 Rumschlag-Booms et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Avian influenza viruses continue to threaten globally with pandemic potential. The first step in a potential pandemic is the ability of the virus to enter human cells which is mediated by the viral surface glycoprotein hemagglutinin HA . Viral entry of influenza is dependent upon the processing of the HA0 polypeptide precursor protein into HA1 and HA2 which is mediated by host cellular proteases. The sequence of the cleavage site which is recognized by host proteases has been linked with pathogenesis of various influenza viruses. Here we examined the effects of .