tailieunhanh - Báo cáo y học: "The impact of the neisserial DNA uptake sequences on genome evolution and stability"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Critical Care giúp cho các bạn có thêm kiến thức về ngành y học đề tài: The impact of the neisserial DNA uptake sequences on genome evolution and stability. | Open Access The impact of the neisserial DNA uptake sequences on genome evolution and stability Todd J TreangenH Ole Herman AmburHn Tone Tonjumn and Eduardo PC Rocha Addresses Algorithms and Genetics Group Department of Computer Science Technical University of Catalonia Jordi Girona Salgado 1-3 E-08034 Barcelona Spain. Centre for Molecular Biology and Neuroscience and Institute of Microbiology University of Oslo Rikshospitalet NO-0027 Oslo Norway. Centre for Molecular Biology and Neuroscience and Institute of Microbiology Rikshospitalet Medical Centre NO-0027 Oslo Norway. Atelier de Bioinformatique UPMC - University of Paris 06 4 Pl Jussieu 75005 Paris France. Microbial Evolutionary Genomics Group URA CNRS 2171 Institut Pasteur 28 R. Dr Roux 75015 Paris France. H These authors contributed equally to this work. Correspondence Eduardo PC Rocha. Email erocha@ Published 26 March 2008 Genome Biology 2008 9 R60 doi 186 gb-2008-9-3-r60 The electronic version of this article is the complete one and can be found online at http 2008 9 3 R60 Received 30 October 2007 Revised 13 January 2008 Accepted 26 March 2008 2008 Treangen et al. licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background Efficient natural transformation in Neisseria requires the presence of short DNA uptake sequences DUSs . Doubts remain whether DUSs propagate by pure selfish molecular drive or are selected for safe sex among conspecifics. Results Six neisserial genomes were aligned to identify gene conversion fragments DUS distribution spacing and conservation. We found a strong link between recombination and DUS DUS spacing matches the size of conversion fragments genomes with shorter conversion fragments have .