tailieunhanh - Báo cáo y học: The Lefe algorithm: embracing the complexity of gene expression in the interpretation of microarray data

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Critical Care giúp cho các bạn có thêm kiến thức về ngành y học đề tài: The embryonic muscle transcriptome of Caenorhabditis elegans. | Research Open Access The embryonic muscle transcriptome of Caenorhabditis elegans Rebecca M Fox Joseph D Watson Stephen E Von Stetina Joan McDermott Thomas M Brodigan Tetsunari Fukushige Michael Krause and David M Miller III Addresses Department of Cell and Developmental Biology Vanderbilt University 465 21st Ave. S. Nashville TN 37232-8240 USA. Graduate Program in Neuroscience Center for Molecular Neuroscience Vanderbilt University Nashville TN 37232-8548 USA. Laboratoiy of Molecular Biology National Institute of Diabetes Digestive and Kidney Diseases National Institutes of Health Building 5 Room B1-04 Bethesda MD 20892 USA. Current address Department of Cell Biology Johns Hopkins University School of Medicine 725 N. Wolfe St. Baltimore MD 21205 USA. Correspondence David M Miller. Email Published 12 September 2007 Genome Biology 2007 8 R188 doi gb-2007-8-9-r1 88 The electronic version of this article is the complete one and can be found online at http 2007 8 9 R188 Received 20 July 2007 Accepted l2 September 2007 2007 Fox et al. licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background The force generating mechanism of muscle is evolutionarily ancient the fundamental structural and functional components of the sarcomere are common to motile animals throughout phylogeny. Recent evidence suggests that the transcription factors that regulate muscle development are also conserved. Thus a comprehensive description of muscle gene expression in a simple model organism should define a basic muscle transcriptome that is also found in animals with more complex body plans. To this end we applied microarray profiling of Caenorhabtidis elegans cells MAPCeL to muscle cell .