tailieunhanh - Báo cáo y học: "The Groucho/TLE/Grg family of transcriptional co-repressors"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Critical Care giúp cho các bạn có thêm kiến thức về ngành y học đề tài: The Groucho/TLE/Grg family of transcriptional co-repressors. | Protein family review The Groucho TLE Grg family of transcriptional co-repressors Barbara H Jennings and David Ish-Horowicz Address Developmental Genetics Laboratory Cancer Research UK Lincoln s Inn Fields London WC2A 3PX UK. Correspondence David Ish-Horowicz. Email Published 31 January 2008 Genome Biology 2008 9 205 doi gb-2008-9-I-205 The electronic version of this article is the complete one and can be found online at http 2008 9 I 205 2008 BioMed Central Ltd Summary The Drosophila Groucho Gro protein was the founding member of the family of transcriptional co-repressor proteins that now includes the transducin-like enhancer of split TLE and Gro-related gene Grg proteins in vertebrates. Gro family proteins do not bind DNA directly but are recruited by a diverse profile of transcription factors including members of the Hes Runx Nkx LEFI Tcf Pax Six and c-Myc families. The primary structure of Gro proteins includes five identifiable regions of which the most highly conserved are the amino-terminal glutamine-rich Q domain and the carboxy-terminal WD-repeat domain. The Q domain contains two coiled-coil motifs that facilitate oligomerization into tetramers and binding to some transcription factors. The WD domain folds to form a P-propeller which mediates protein-protein interactions. Many transcription factors interact with the WD domain via a short peptide motif that falls into either of two classes WRPW and related tetrapeptides and the eh I motif FxIxxIL . Gro family proteins are broadly expressed during development and in the adult. They have essential functions in many developmental pathways including Notch and Wnt signaling and are implicated in the pathogenesis of some cancers. The molecular mechanisms through which Gro proteins act to repress transcription are not yet well understood. It is becoming clear that Gro proteins have different modes of action in vivo dependent on biological context and these .