tailieunhanh - Báo cáo khoa học: "The ORF59 DNA polymerase processivity factor homologs of Old World primate RV2 rhadinoviruses are highly conserved nuclear antigens expressed in differentiated epithelium in infected macaques"

Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài: The ORF59 DNA polymerase processivity factor homologs of Old World primate RV2 rhadinoviruses are highly conserved nuclear antigens expressed in differentiated epithelium in infected macaques | Virology Journal BioMed Central Research The ORF59 DNA polymerase processivity factor homologs of Old World primate RV2 rhadinoviruses are highly conserved nuclear antigens expressed in differentiated epithelium in infected macaques A Gregory Bruce1 Angela M Bakke1 Courtney A Gravett1 Laura K DeMaster1 Helle Bielefeldt-Ohmann2 Kellie L Burnside1 and Timothy M Rose 1 3 Address 1Center for Childhood Infection and Prematurity Research Seattle Children s Research Institute 1900 Ninth Ave Seattle WA 981011304 USA 2School of Veterinary Science University of Queensland Brisbane Qld Australia and 3Department of Pediatrics University of Washington Seattle WA 98195 USA Email A Gregory Bruce - Angela M Bakke - angiebakke@ Courtney A Gravett - Laura K DeMaster - Helle Bielefeldt-Ohmann - Kellie L Burnside - Timothy M Rose - trose@ Corresponding author Open Access Published 18 November 2009 Virology Journal 2009 6 205 doi I743-422X-6-205 Received 20 July 2009 Accepted 18 NOvember 2009 This article is available from http content 6 1 205 2009 Bruce et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background ORF59 DNA polymerase processivity factor of the human rhadinovirus Kaposi s sarcoma-associated herpesvirus KSHV is required for efficient copying of the genome during virus replication. KSHV ORF59 is antigenic in the infected host and is used as a marker for virus activation and replication. Results We cloned sequenced and expressed the genes encoding related ORF59 proteins from the RV1 rhadinovirus .