tailieunhanh - Báo cáo y học: "Functionally important segments in proteins dissected using Gene Ontology and geometric clustering of peptide fragments"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Critical Care giúp cho các bạn có thêm kiến thức về ngành y học đề tài: Functionally important segments in proteins dissected using Gene Ontology and geometric clustering of peptide fragments. | Open Access Functionally important segments in proteins dissected using Gene Ontology and geometric clustering of peptide fragments Karuppasamy Manikandan Debnath Pal Suryanarayanarao Ramakumar Nathan E Brener Sitharama S Iyengar and Guna Seetharaman Addresses Bioinformatics Centre Indian Institute of Science Bangalore 560012 India. Department of Physics Indian Institute of Science Bangalore 560012 India. Supercomputer Education and Research Centre Indian Institute of Science Bangalore 560012 India. Department of Computer Science Louisiana State University Baton Rouge LA 70803 USA. Main correspondence. Correspondence Debnath Pal. Email dpal@. Suryanarayanarao Ramakumar. Email ramak@ Published 10 March 2008 Genome Biology 2008 9 R52 doi 186 gb-2008-9-3-r52 The electronic version of this article is the complete one and can be found online at http 2008 9 3 R52 Received 30 November 2007 Revised 24 February 2008 Accepted 10 March 2008 2008 Karuppasamy et al. licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract We have developed a geometric clustering algorithm using backbone ộ y angles to group conformationally similar peptide fragments of any length. By labeling each fragment in the cluster with the level-specific Gene Ontology molecular function term of its protein we are able to compute statistics for molecular function-propensity and p-value of individual fragments in the cluster. Clustering-cum-statistical analysis for peptide fragments 8 residues in length and with only trans peptide bonds shows that molecular function propensities 20 and p-values can dissect fragments within a protein linked to the molecular function. Background Analysis of the protein

TÀI LIỆU LIÊN QUAN
TỪ KHÓA LIÊN QUAN
TÀI LIỆU MỚI ĐĂNG
22    121    0    29-04-2024
10    118    0    29-04-2024
33    125    0    29-04-2024
1    114    1    29-04-2024
24    110    0    29-04-2024
11    101    0    29-04-2024
crossorigin="anonymous">
Đã phát hiện trình chặn quảng cáo AdBlock
Trang web này phụ thuộc vào doanh thu từ số lần hiển thị quảng cáo để tồn tại. Vui lòng tắt trình chặn quảng cáo của bạn hoặc tạm dừng tính năng chặn quảng cáo cho trang web này.