tailieunhanh - Báo cáo y học: "Complexity and integration in the control of inner-ear development"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Critical Care giúp cho các bạn có thêm kiến thức về ngành y học đề tài: Complexity and integration in the control of inner-ear development. | Meeting report Complexity and integration in the control of inner-ear development Donald L Swiderski Tzy-Wen Gong and Mirna Mustapha Addresses Kresge Hearing Research Institute University of Michigan Ann Arbor MI 48109 USA. Human Genetics Department University of Michigan Ann Arbor MI 48109 USA. Correspondence Mirna Mustapha. Email mirnam@ Published 1 October 2007 Genome Biology 2007 8 315 doi gb-2007-8-9-315 The electronic version of this article is the complete one and can be found online at http 2007 8 9 315 2007 BioMed Central Ltd A report on the Sixth Molecular Biology of Hearing and Deafness Conference Hinxton UK 11-14 July 2007. A meeting held this summer at the Sanger Centre outside Cambridge UK focused on the molecular biology of hearing and deafness. Although several proteins are uniquely expressed in the vertebrate inner ear these are primarily found in the sensory hair cells where they form key components of the mechanosensitive stereocilia the hairs of the organ of Corti in the cochlea. In general inner-ear development is guided by the same suites of genes that control development in other neurogenic tissues making the inner ear a good model system for studying the genetic regulation of development. In this light we will focus here on discoveries relating to morphogenesis and cell-fate determination the control of gene expression by microRNAs identification of deafness-associated genes and implications of developmental studies for the remediation of hearing loss. Inner-ear development Many studies have looked at the overlapping roles of fibroblast growth factors FGFS in inner-ear development. The work on chick presented by Raj Ladher RIKEN Kobe Japan was unusual in focusing on the morphogenetic response of the otic placode to FGF signaling. As might be predicted from morphogenesis in other tissues a key component of the transformation from placode to otic vesicle is a change in cell shape. Ladher reported that FGF .