tailieunhanh - Báo cáo y học: " Gene-expression patterns reveal underlying biological processes in Kawasaki diseas"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Critical Care giúp cho các bạn có thêm kiến thức về ngành y học đề tài: Gene-expression patterns reveal underlying biological processes in Kawasaki disease. | Open Access Research Gene-expression patterns reveal underlying biological processes in Kawasaki disease Stephen J Popper Chisato Shimizu Hiroko Shike John T Kanegaye Jane W Newburger Robert P Sundel Patrick O Brown Jane C Burns and David A Relman Addresses Departments of Microbiology and Immunology and Medicine Stanford University School of Medicine Stanford CA 94305 USA. Department of Pediatrics University of California San Diego School of Medicine La Jolla CA 92093 and Rady Children s Hospital San Diego San Diego CA 92123 USA. Departments of Cardiology and Pediatrics Children s Hospital Boston and Harvard Medical School Boston MA 02115 USA. Department of Biochemistry Stanford University School of Medicine Stanford CA 94305 USA. Veterans Affairs Palo Alto Health Care System Palo Alto CA 94304 USA. Correspondence Stephen J Popper. Email spopper@ Published II December 2007 Genome Biology 2007 8 R261 doi gb-2007-8- I2-r26I The electronic version of this article is the complete one and can be found online at http 2007 8 I2 R26I Received 2 April 2007 Revised 13 July 2007 Accepted II December 2007 2007 Popper et al. licensee BioMed Central Ltd. Abstract Background Kawasaki disease KD is an acute self-limited vasculitis and the leading cause of acquired heart disease in children in developed countries. No etiologic agent s has been identified and the processes that mediate formation of coronary artery aneurysms and abatement of fever following treatment with intravenous immunoglobulin IVIG remain poorly understood. Results In an initial survey we used DNA microarrays to examine patterns of gene expression in peripheral whole blood from 20 children with KD each was sampled during the acute subacute and convalescent phases of the illness. Acute KD was characterized by increased relative abundance of gene transcripts associated with innate immune and proinflammatory responses and decreased abundance of transcripts associated with .