tailieunhanh - Báo cáo y học: "MicroRNAs show a wide diversity of expression profiles in the developing and mature central nervous system"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Critical Care giúp cho các bạn có thêm kiến thức về ngành y học đề tài: MicroRNAs show a wide diversity of expression profiles in the developing and mature central nervous system. | Open Access MicroRNAs show a wide diversity of expression profiles in the developing and mature central nervous system Marika KapsimaliH n Wigard P KloostermanH Ewart de Bruijn Frederic Rosa Ronald HA Plasterk and Stephen W Wilson Addresses Department of Anatomy and Developmental Biology UCL Gower Street London WC1E 6BT UK. tDEPSN UPR2197 CNRS avenue de la Terrasse 91198 Gif-sur-Yvette France. Génétique Moléculaire du Développement INSERM U784 Ecole Normale Supérieure 46 rue d Ulm 75230 Paris France. Hubrecht Laboratory Centre for Biomedical Genetics Uppsalalaan 8 3584 CT Utrecht the Netherlands. Génétique Moléculaire du Développement INSERM U784 Ecole Normale Supérieure 46 rue d Ulm 75230 Paris France. H These authors contributed equally to this work. Correspondence Ronald HAPlasterk. Email plasterk@. Stephen W Wilson. Email Published 21 August 2007 Genome Biology 2007 8 RI73 doi gb-2007-8-8-rI73 The electronic version of this article is the complete one and can be found online at http 2006 8 8 R173 Received 16 January 2007 Revised 24 May 2007 Accepted 2I August 2007 2007 Kapsimali et al. licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background MicroRNA miRNA encoding genes are abundant in vertebrate genomes but very few have been studied in any detail. Bioinformatic tools allow prediction of miRNA targets and this information coupled with knowledge of miRNA expression profiles facilitates formulation of hypotheses of miRNA function. Although the central nervous system CNS is a prominent site of miRNA expression virtually nothing is known about the spatial and temporal expression profiles of miRNAs in the brain. To provide an overview of the breadth of .