tailieunhanh - Báo cáo y học: "Quantitative genomics of locomotor behavior in Drosophila melanogast"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Critical Care giúp cho các bạn có thêm kiến thức về ngành y học đề tài:Quantitative genomics of locomotor behavior in Drosophila melanogaster. | Research Open Access Quantitative genomics of locomotor behavior in Drosophila melanogaster Katherine W Jordan Mary Anna Carbone Akihiko Yamamoto Theodore J Morgan and Trudy FC Mackay Addresses Department of Genetics and WM Keck Center for Behavioral Biology North Carolina State University Raleigh NC 27695-7614 USA. Division of Biology Kansas State University Ackert Hall Manhattan KS 66506 USA. Correspondence Trudy FC Mackay. Email trudy_mackay@ Published 21 August 2007 Genome Biology 2007 8 R172 doi gb-2007-8-8-rl 72 The electronic version of this article is the complete one and can be found online at http 2007 8 8 R172 Received 18 December 2006 Revised 26 March 2007 Accepted 21 August 2007 2007 Jordan et al. licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background Locomotion is an integral component of most animal behaviors and many human health problems are associated with locomotor deficits. Locomotor behavior is a complex trait with population variation attributable to many interacting loci with small effects that are sensitive to environmental conditions. However the genetic basis of this complex behavior is largely uncharacterized. Results We quantified locomotor behavior of Drosophila melanogaster in a large population of inbred lines derived from a single natural population and derived replicated selection lines with different levels of locomotion. Estimates of broad-sense and narrow-sense heritabilities were and respectively indicating substantial non-additive genetic variance for locomotor behavior. We used whole genome expression analysis to identify 1 790 probe sets with different expression levels between the selection lines when pooled across replicates .