tailieunhanh - Báo cáo khoa học: " Cassette deletion in multiple shRNA lentiviral vectors for HIV-1 and its impact on treatment success"

Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài: Cassette deletion in multiple shRNA lentiviral vectors for HIV-1 and its impact on treatment success | Virology Journal BioMed Central Open Access Cassette deletion in multiple shRNA lentiviral vectors for HIV-1 and its impact on treatment success Glen J Mcintyre 1 Yi-Hsin Yu1 Anna Tran1 Angel B Jaramillo1 Allison J Arndt1 Michelle L Millington1 Maureen P Boyd1 Fiona A Elliott1 Sylvie W Shen1 John M Murray2 3 and Tanya L Applegate1 Address Johnson and Johnson Research Pty Ltd Level 4 Biomedical Building 1 Central Avenue Australian Technology Park Eveleigh NSW 1430 Australia 2School of Mathematics and Statistics The University of New South Wales Sydney NSW 2052 Australia and 3The National Center in HIV Epidemiology and Clinical Research The University of New South Wales 376 Victoria St. Darlinghurst NSW 2010 Australia Email Glen J Mcintyre - glen@ Yi-Hsin Yu - yyu11@ Anna Tran - Angel B Jaramillo - Allison J Arndt - Michelle L Millington - michellemillington5@ Maureen P Boyd - maureenpboyd@ Fiona A Elliott - fionaae@ Sylvie W Shen - swshen@ John M Murray - Tanya L Applegate - Corresponding author Published 30 October 2009 Received 14 May 2009 Accepted 30 October 2009 Virology Journal 2009 6 184 doi I743-422X-6-I84 This article is available from http content 6 1 184 2009 Mcintyre et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background Multiple short hairpin RNA shRNA gene therapy strategies are currently being investigated for treating viral diseases such as HIV-1. It is important to use several different shRNAs to prevent the emergence of treatment-resistant strains. However there is evidence that .