tailieunhanh - Báo cáo y học: "Quantifying the major mechanisms of recent gene duplications in the human and mouse genomes: a novel strategy to estimate gene duplication rates"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Critical Care giúp cho các bạn có thêm kiến thức về ngành y học đề tài:Quantifying the major mechanisms of recent gene duplications in the human and mouse genomes: a novel strategy to estimate gene duplication rates. | Open Access Research Quantifying the major mechanisms of recent gene duplications in the human and mouse genomes a novel strategy to estimate gene duplication rates Deng Pan and Liqing Zhang Address Department of Computer Science Virginia Tech Torgerson Hall Blacksburg Virginia 24061-0106 USA. Correspondence Liqing Zhang. Email lqzhang@ Published 2 August 2007 Genome Biology 2007 8 RI58 doi gb-2007-8-8-rl 58 The electronic version of this article is the complete one and can be found online at http 2007 8 8 R158 Received 1 June 2007 Revised II July 2007 Accepted 2 August 2007 2007 Pan et al. licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background The rate of gene duplication is an important parameter in the study of evolution but the influence of gene conversion and technical problems have confounded previous attempts to provide a satisfying estimate. We propose a new strategy to estimate the rate that involves separate quantification of the rates of two different mechanisms of gene duplication and subsequent combination of the two rates based on their respective contributions to the overall gene duplication rate. Results Previous estimates of gene duplication rates are based on small gene families. Therefore to assess the applicability of this to families of all sizes we looked at both two-copy gene families and the entire genome. We studied unequal crossover and retrotransposition and found that these mechanisms of gene duplication are largely independent and account for a substantial amount of duplicated genes. Unequal crossover contributed more to duplications in the entire genome than retrotransposition did but this contribution was significantly less in two-copy gene families