tailieunhanh - Báo cáo y học: "Complexity, connectivity, and duplicability as barriers to lateral gene transfe"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Critical Care giúp cho các bạn có thêm kiến thức về ngành y học đề tài:Complexity, connectivity, and duplicability as barriers to lateral gene transfer. | Open Access Research Complexity connectivity and duplicability as barriers to lateral gene transfer Alon Wellner Mor N Lurie and Uri Gophna Address Department of Molecular Microbiology and Biotechnology George S Wise Faculty of Life Sciences Tel Aviv University Tel Aviv Israel 69978. Correspondence Uri Gophna. Email urigo@ Published 2 August 2007 Genome Biology 2007 8 RI56 doi gb-2007-8-8-rl 56 The electronic version of this article is the complete one and can be found online at http 2007 8 8 R156 Received 16 April 2007 Revised 10 July 2007 Accepted 2 August 2007 2007 Wellner et al. licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background Lateral gene transfer is a major force in microbial evolution and a great source of genetic innovation in prokaryotes. Protein complexity has been claimed to be a barrier for gene transfer due to either the inability of a new gene s encoded protein to become a subunit of an existing complex lack of positive selection or from a harmful effect exerted by the newcomer on native protein assemblages negative selection . Results We tested these scenarios using data from the model prokaryote Escherichia coli. Surprisingly the data did not support an inverse link between membership in protein complexes and gene transfer. As the complexity hypothesis in its strictest sense seemed valid only to essential complexes we broadened its scope to include connectivity in general. Transferred genes are found to be less involved in protein-protein interactions outside stable complexes and this is especially true for genes recently transferred to the E. coli genome. Thus subsequent to transfer new genes probably integrate slowly into existing .