tailieunhanh - Báo cáo khoa học: " Age-dependent resistance to Porcine reproductive and respiratory syndrome virus replication in swine"

Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài: Age-dependent resistance to Porcine reproductive and respiratory syndrome virus replication in swine | Virology Journal BioMed Central Research Age-dependent resistance to Porcine reproductive and respiratory syndrome virus replication in swine Kelly L Klinge1 Eric M Vaughn1 Michael B Roof1 Elida M Bautista2 and Michael P Murtaugh 3 Address Boehringer Ingelheim Vetmedica Inc 2501 North Loop Drive Suite 1000 Ames IA 50014 USA 2Boehringer Ingelheim Vetmedica 2621 N Belt Highway St Joseph MO 64506 USA and Department of Veterinary and Biomedical Sciences University of Minnesota 1971 Commonwealth Avenue St Paul MN 55108 USA Email Kelly L Klinge - Eric M Vaughn - Michael B Roof - Elida M Bautista - Michael P Murtaugh - murta001@ Corresponding author Open Access Published 27 October 2009 Received 20 July 2009 J- .IA I loz i-zai amv z 1-7-7 Accepted 27 October 2009 Virology Journal 2009 6 177 doi 1743-422X-6-177 This article is available from http content 6 1 177 2009 Klinge et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract_ Background Porcine reproductive and respiratory syndrome virus PRRSV causes a prolonged economically devastating infection in pigs and immune resistance to infection appears variable. Since the porcine adaptive immune system is not fully competent at birth we hypothesized that age influences the dynamics of PRRSV infection. Thus young piglets growing 16-20-week-old finisher pigs and mature third parity sows were infected with virulent or attenuated PRRSV and the dynamics of viral infection disease and immune response were