tailieunhanh - Báo cáo y học: "Spore germination in Saccharomyces cerevisiae: global gene expression patterns and cell cycle landmarks"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Critical Care giúp cho các bạn có thêm kiến thức về ngành y học đề tài: Spore germination in Saccharomyces cerevisiae: global gene expression patterns and cell cycle landmarks. | Open Access Spore germination in Saccharomyces cerevisiae global gene expression patterns and cell cycle landmarks Daphna Joseph-Strauss Drora Zenvirth Giora Simchen and Naama Barkai Addresses Departments of Molecular Genetics and Physics of Complex System Weizmann Institute of Science Rehovot 76100 Israel. Department of Genetics The Hebrew University of Jerusalem Jerusalem 91904 Israel. Correspondence Giora Simchen. Email Simchen@. Naama Barkai. Email Published 14 November 2007 Genome Biology 2007 8 R241 doi gb-2007-8- 11-r241 The electronic version of this article is the complete one and can be found online at http 2007 8 ll R24l Received 28 August 2007 Revised 7 October 2007 Accepted 14 November 2007 2007 Joseph-Strauss et al. licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background Spore germination in the yeast Saccharomyces cerevisiae is a process in which nondividing haploid spores re-enter the mitotic cell cycle and resume vegetative growth. To study the signals and pathways underlying spore germination we examined the global changes in gene expression and followed cell-cycle and germination markers during this process. Results We find that the germination process can be divided into two distinct stages. During the first stage the induced spores respond only to glucose. The transcription program during this stage recapitulates the general transcription response of yeast cells to glucose. Only during the second phase are the cells able to sense and respond to other nutritional components in the environment. Components of the mitotic machinery are involved in spore germination but in a distinct pattern. In contrast to the mitotic cell cycle