tailieunhanh - Báo cáo khoa học: " The inhibition of assembly of HIV-1 virus-like particles by 3-O-(3',3'-dimethylsuccinyl) betulinic acid (DSB) is counteracted by Vif and requires its Zinc-binding domain"

Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài: The inhibition of assembly of HIV-1 virus-like particles by 3-O-(3',3'-dimethylsuccinyl) betulinic acid (DSB) is counteracted by Vif and requires its Zinc-binding domain | BioMed Central Virology Journal Open Access The inhibition of assembly of HIV-I virus-like particles by 3-O- 3 3 -dimethylsuccinyl betulinic acid DSB is counteracted by Vif and requires its Zinc-binding domain Sandrina DaFonseca1 Pascale Coric2 Bernard Gay3 4 Saw See Hong1 Serge Bouaziz2 and Pierre Boulanger 1 3 4 Address 1Université de Lyon I - Claude Bernard Faculté de Médecine Laennec Laboratoire de Virologie Pathologie Humaine CNRS FRE-3011 69372 Lyon Cedex 08 France 2Université de Paris VII - René Descartes UFR des Sciences Pharmaceutiques et Biologiques Unité de Pharmacologie Chimique et Génétique INSERM U-640 and CNRS UMR-8151 75006 Paris France 3Universités de Montpellier I et II Centre d Etudes d Agents Pathogènes et Biotechnologies pour la santé CNRS UMR-5236 Institut de Biologie 4 Boulevard Henri IV 34965 Montpellier Cedex 02 France and 4Laboratoire de Virologie Médicale Centre de Biologie et Pathologie Est Hospices Civils de Lyon 59 Boulevard Pinel 69677 Bron Cedex France Email Sandrina DaFonseca - sandrinedafonseca@ Pascale Coric - Bernard Gay - Saw See Serge Pierre Boulanger - Corresponding author Published 23 December 2008 Received 6 November 2008 Accepted 23 December 2008 Virology Journal 2008 5 162 doi 1743-422X-5-162 This article is available from http content 5 1 162 2008 DaFonseca et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background DSB the 3-O- 3 3 dimethylsuccinyl derivative of betulinic acid blocks the last step of protease-mediated processing of HIV-1 Gag precursor Pr55Gag which leads to