tailieunhanh - Báo cáo khoa học: "Extensive purifying selection acting on synonymous sites in HIV-1 Group M sequences"

Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài: Extensive purifying selection acting on synonymous sites in HIV-1 Group M sequences | Virology Journal BioMed Zentral Research Open Access Extensive purifying selection acting on synonymous sites in HIV-1 Group M sequences Nobubelo K Ngandu1 Konrad Scheffler2 Penny Moore3 Zenda Woodman4 Darren Martin4 and Cathal Seoighe 1 Address 1National Bioinformatics Network Node Institute of Infectious Diseases and Molecular Medicine Faculty of Health Sciences University of Cape Town Anzio Road Observatory 7925 South Africa 2Computer Science Division Dept of Mathematical Sciences University of Stellenbosch Private Bag X1 7602 Matieland Stellenbosch South Africa 3National Institute for Communicable Diseases Private Bag X4 Sandringham Johannesburg 2131 South Africa and 4HIV Diversity and Pathogenesis Group Institute of Infectious Diseases and Molecular Medicine Faculty of Health Sciences University of Cape Town Anzio Road Observatory 7925 Cape Town South Africa E-mail Nobubelo K Ngandu - nobubelo@ Konrad Scheffler - konrad@ Penny Moore - pennym@ Zenda Woodman - Darren Martin - Cathal Seoighe - cseoighe@ Corresponding author Published 23 December 2008 Received 2 December 2008 Virology Journal 2008 5 160 doi 186 1743-422X-5-160 Accepted 23 December 2008 This article is available from http content 5 1 160 2008 Ngandu et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background Positive selection pressure acting on protein-coding sequences is usually inferred when the rate of nonsynonymous substitution is greater than the synonymous rate. However purifying selection acting directly on the nucleotide sequence can lower the synonymous substitution rate. This could result in false inference of .