tailieunhanh - Báo cáo y học: "Early corticosteroid treatment for severe pneumonia caused by 2009 H1N1 influenza virus"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Critical Care giúp cho các bạn có thêm kiến thức về ngành y học đề tài: Early corticosteroid treatment for severe pneumonia caused by 2009 H1N1 influenza virus. | Kil et al. Critical Care 2011 15 413 http content 15 2 413 CRITICAL CARE LETTER L_ Early corticosteroid treatment for severe pneumonia caused by 2009 H1N1 influenza virus Hong-Ryang Kil1 Jae-Ho Lee1 Kyung-Yil Lee 2 3 Jung-Woo Rhim2 3 You-Sook Youn2 3 and Jin-Han Kang3 A pandemic of the 2009 H1N1 influenza A virus infection occurred worldwide in 2009. Some previously healthy patients experienced rapidly progressive pneumonia leading to acute respiratory distress syndrome ARDS and even death. The effect of corticosteroids on these severely affected patients is controversial because of a lack of controlled clinical trials 1 . During the pandemic in South Korea we observed that early short-term corticosteroid treatment along with oseltamivir seemed to have a dramatic effect on patients with severe pneumonia and we proposed a new theory for the pathogenesis of acute lung injury in influenza virus infections 2 . In that study we wanted to evaluate this beneficial effect of corticosteroid treatment through comparative data based on the use or non-use of corticosteroids at two separate hospitals. The subjects of the study were the pneumonia patients who had severe respiratory distress with hypoxemia at presentation or during admission and who thus required oxygen therapy. The conditions of 17 patients median of 6 years of age range of 4 to 9 in our hospital The Catholic University of Korea Daejeon St Mary s Hospital Daejeon South Korea use of corticosteroids and 15 patients median of 6 years of age range of 5 to 18 in a neighboring hospital Chungnam National University Hospital Daejeon South Korea non-use of corticosteroids were diagnosed by reverse transcriptase-polymerase chain reaction. The clinical and laboratory characteristics of patients in the two hospitals are shown in Table 1. Our results suggested that the severe pneumonia patients who were treated with corticosteroids showed shortened durations of fever and oxygen therapy rapid resolution of .