tailieunhanh - Báo cáo y học: "Inferring genome-scale rearrangement phylogeny and ancestral gene order: a Drosophila case study"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Critical Care giúp cho các bạn có thêm kiến thức về ngành y học đề tài: Inferring genome-scale rearrangement phylogeny and ancestral gene order: a Drosophila case study. | Open Access Method Inferring genome-scale rearrangement phylogeny and ancestral gene order a Drosophila case study Arjun Bhutkar William M GelbarF and Temple F Smith Addresses BioMolecular Engineering Research Center Boston University Cummington St Boston MA 02215 USA. Department of Molecular and Cellular Biology Harvard University Cambridge MA 021383 USA. Correspondence Arjun Bhutkar. Email arjunb@ Published 8 November 2007 Genome Biology 2007 8 R236 doi gb-2007-8-ll-r236 The electronic version of this article is the complete one and can be found online at http 2007 8 ll R236 Received 6 May 2007 Revised 17 September 2007 2007 Bhutkar et al. licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract A simple fast and biologically inspired computational approach for inferring genome-scale rearrangement phylogeny and ancestral gene order has been developed. This has been applied to eight Drosophila genomes. Existing techniques are either limited to a few hundred markers or a small number of taxa. This analysis uses over 14 000 genomic loci and employs discrete elements consisting of pairs of homologous genetic elements. The results provide insight into evolutionary chromosomal dynamics and synteny analysis and inform speciation studies. Background Chromosomal rearrangements have been studied in Drosophila since the early 20th century originally via optical observation of banding patterns 1-4 . Chromosomal inversions have been inferred from such observations as well as from other genomic marker pairs 2 5-7 . These inversions and clusters of banding patterns have also been used to study evolutionary history 8 9 adaptation and speciation 10 11 . More recently the identification and .