tailieunhanh - Báo cáo y học: "Gene expression atlas of the mouse central nervous system: impact and interactions of age, energy intake and gender"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Critical Care giúp cho các bạn có thêm kiến thức về ngành y học đề tài: Gene expression atlas of the mouse central nervous system: impact and interactions of age, energy intake and gender. | Open Access Gene expression atlas of the mouse central nervous system impact and interactions of age energy intake and gender Xiangru Xu Ming Zhan Wenzhen Duan Vinayakumar Prabhu Randall Brenneman William Wood Jeff Firman Huai Li Peisu Zhang Carol Ibe Alan B Zonderman Dan L Longo Suresh Poosala Kevin G Becker and Mark P Mattson Addresses Laboratory of Neurosciences National Institute on Aging Intramural Research Program 5600 Nathan Shock Drive Baltimore MD 21224 USA. Research Resources Branch National Institute on Aging Intramural Research Program 5600 Nathan Shock Drive Baltimore MD 21224 USA. Laboratory of Immunology National Institute on Aging Intramural Research Program 5600 Nathan Shock Drive Baltimore MD 21224 USA. Correspondence Mark P Mattson. Email MattsonM@ Published 7 November 2007 Genome Biology 2007 8 R234 doi gb-2007-8- 11-r234 The electronic version of this article is the complete one and can be found online at http 2007 8 11 R234 Received 14 June 2007 Revised 13 July 2007 Accepted 7 November 2007 2007 Xu et al. licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background The structural and functional complexity of the mammalian central nervous system CNS is organized and modified by complicated molecular signaling processes that are poorly understood. Results We measured transcripts of 16 896 genes in 5 CNS regions from cohorts of young middle-aged and old male and female mice that had been maintained on either a control diet or a low energy diet known to retard aging. Each CNS region cerebral cortex hippocampus striatum cerebellum and spinal cord possessed its own unique transcriptome fingerprint that was independent of age gender and energy intake. Less than