tailieunhanh - Báo cáo y học: "Endothelial Balanced massive transfusion ratios in multiple injury patients with traumatic brain injury"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Critical Care giúp cho các bạn có thêm kiến thức về ngành y học đề tài: Endothelial Balanced massive transfusion ratios in multiple injury patients with traumatic brain injury. | Peiniger et al. Critical Care 2011 15 R68 http content 15 1 R68 KS CRITICAL CARE RESEARCH Open Access Balanced massive transfusion ratios in multiple injury patients with traumatic brain injury Sigune Peiniger1 2 Ulrike Nienaber2 Rolf Lefering2 Maximilian Braun1 2 Arasch Wafaisade1 2 Sebastian Wutzler1 Matthew Borgmann3 Philip C Spinella4 and Marc Maegele1 2 for the Trauma Registry of the Deutsche Gesellschaft fur Unfallchirurgie TR-DGU Abstract Introduction Retrospective studies have demonstrated a potential survival benefit from transfusion strategies using an early and more balanced ratio between fresh frozen plasma FFP concentration and packed red blood cell pRBC transfusions in patients with acute traumatic coagulopathy requiring massive transfusions. These results have mostly been derived from non-head-injured patients. The aim of the present study was to analyze whether a regime using a high FFP pRBC transfusion ratio FFP pRBC ratio 1 2 would be associated with a similar survival benefit in severely injured patients with traumatic brain injury TBI Abbreviated Injury Scale AIS score head 3 as demonstrated for patients without TBI requiring massive transfusion 10 U of pRBCs . Methods A retrospective analysis of severely injured patients from the Trauma Registry of the Deutsche Gesellschaft fur Unfallchirurgie TR-DGU was conducted. Inclusion criteria were primary admission age 16 years severe injury Injury Severity Score ISS 16 and massive transfusion 10 U of pRBCs from emergency room to intensive care unit ICU . Patients were subdivided into patients with TBI AIS score head 3 and patients without TBI AIS score head 3 as well as according to the transfusion ratio they had received high FFP pRBC ratio FFP pRBC ratio 1 2 and low FFP pRBC ratio FFP pRBC ratio 1 2 . In addition morbidity and mortality between the two groups were compared. Results A total of 1 250 data sets of severely injured patients from the TR-DGU between 2002 and 2008 were analyzed.