tailieunhanh - Báo cáo y học: " Endothelial Postresuscitation care with mild therapeutic hypothermia and coronary intervention after out-of-hospital cardiopulmonary resuscitation: a prospective registry analysi"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Critical Care giúp cho các bạn có thêm kiến thức về ngành y học đề tài: Endothelial Postresuscitation care with mild therapeutic hypothermia and coronary intervention after out-of-hospital cardiopulmonary resuscitation: a prospective registry analysis. | Grăsner et al. Critical Care 2011 15 R61 http content 15 1 R61 KS CRITICAL CARE RESEARCH Open Access Postresuscitation care with mild therapeutic hypothermia and coronary intervention after out-of-hospital cardiopulmonary resuscitation a prospective registry analysis 1 t 1t 2 3 1 4 Jan Thorsten Grasner Patrick Meybohm Amke Caliebe Bernd W Bottiger Jan Wnent Martin Messelken 5 6 7 8 K9 71 r4 Tanja Jantzen Thorsten Zeng Bernd Strickmann Andreas Bohn Hans Fischer Jens Scholz Matthias Fischer for the German Resuscitation Registry Study Group Abstract Introduction Mild therapeutic hypothermia MTH has been shown to result in better neurological outcome after cardiopulmonary resuscitation. Percutaneous coronary intervention PCI may also be beneficial in patients after out-of-hospital cardiac arrest OHCA . Methods A selected cohort study of 2 973 prospectively documented adult OHCA patients within the German Resuscitation Registry between 2004 and 2010. Data were analyzed by backwards stepwise binary logistic regression to identify the impact of MTH and PCI on both 24-hour survival and neurological outcome that was based on cerebral performance category CPC at hospital discharge. Odds ratios 95 confidence intervals were calculated adjusted for the following confounding factors age location of cardiac arrest presumed etiology bystander cardiopulmonary resuscitation witnessing first electrocardiogram rhythm and thrombolysis. Results The Preclinical care dataset included 2 973 OHCA patients with 44 initial return of spontaneous circulation n 1 302 and 35 hospital admissions n 1 040 . Seven hundred and eleven out of these 1 040 OHCA patients 68 were also registered within the Postresuscitation care dataset. Checking for completeness of datasets required the exclusion of 127 Postresuscitation care cases leaving 584 patients with complete data for final analysis. In patients without PCI n 430 MTH was associated with increased 24-hour survival to P .