tailieunhanh - Báo cáo y học: "Surprising complexity of the ancestral apoptosis network"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Critical Care giúp cho các bạn có thêm kiến thức về ngành y học đề tài: Surprising complexity of the ancestral apoptosis network. | Open Access Research Surprising complexity of the ancestral apoptosis network Christian M Zmasekn Qing Zhangn Yuzhen Ye and Adam Godzik Addresses Burnham Institute for Medical Research North Torrey Pines Road La Jolla CA 92037 USA. School of Informatics Indiana University Street Bloomington IN 47408 USA. Skaggs School of Pharmacy and Pharmaceutical Sciences University of California San Diego Gilman Drive La Jolla CA 92093 USA. n These authors contributed equally to this work. Correspondence Adam Godzik. Email adam@ Published 24 October 2007 Genome Biology 2007 8 R226 doi gb-2007-8- l0-r226 The electronic version of this article is the complete one and can be found online at http 2007 8 10 R226 Received 20 July 2007 Revised 24 October 2007 Accepted 24 October 2007 2007 Zmasek et al licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background Apoptosis one of the main types of programmed cell death is regulated and performed by a complex protein network. Studies in model organisms mostly in the nematode Caenorhabditis elegans identified a relatively simple apoptotic network consisting of only a few proteins. However analysis of several recently sequenced invertebrate genomes ranging from the cnidarian sea anemone Nematostella vectensis representing one of the morphologically simplest metazoans to the deuterostomes sea urchin and amphioxus contradicts the current paradigm of a simple ancestral network that expanded in vertebrates. Results Here we show that the apoptosome-forming CED-4 Apaf-l protein present in single copy in vertebrate nematode and insect genomes had multiple paralogs in the cnidarian-bilaterian ancestor. Different members of this ancestral Apaf-l family led to