tailieunhanh - Báo cáo y học: "Reversible and permanent effects of tobacco smoke exposure on airway epithelial gene expression"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Critical Care giúp cho các bạn có thêm kiến thức về ngành y học đề tài:Reversible and permanent effects of tobacco smoke exposure on airway epithelial gene expression. | Open Access Research Reversible and permanent effects of tobacco smoke exposure on airway epithelial gene expression Jennifer Beane Paola Sebastian Gang Liu Jerome S Brody Marc E Lenburg and Avrum Spira Addresses Bioinformatics Program Boston University Cummington Street Boston MA 02215 USA. The Pulmonary Center Boston University Medical Center Albany Street Boston MA 02118 USA. School of Public Health Boston University Albany Street Boston MA 02118 USA. Department of Genetics and Genomics Boston University Albany Street Boston MA 02118 USA. Correspondence Jennifer Beane. Email jbeane@ Published 25 September 2007 Genome Biology 2007 8 R201 doi gb-2007-8-9-r20l The electronic version of this article is the complete one and can be found online at http 2007 8 9 R201 Received 8 January 2007 Revised 17 September 2007 Accepted 25 September 2007 2007 Beane et al licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background Tobacco use remains the leading preventable cause of death in the US. The risk of dying from smoking-related diseases remains elevated for former smokers years after quitting. The identification of irreversible effects of tobacco smoke on airway gene expression may provide insights into the causes of this elevated risk. Results Using oligonucleotide microarrays we measured gene expression in large airway epithelial cells obtained via bronchoscopy from never current and former smokers n 104 . Linear models identified 175 genes differentially expressed between current and never smokers and classified these as irreversible n 28 slowly reversible n 6 or rapidly reversible n 139 based on their expression in former smokers. A greater percentage of irreversible and slowly .