tailieunhanh - Báo cáo y học: "Cell-specific microarray profiling experiments reveal a comprehensive picture of gene expression in the C. elegans nervous system"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Critical Care giúp cho các bạn có thêm kiến thức về ngành y học đề tài: Cell-specific microarray profiling experiments reveal a comprehensive picture of gene expression in the C. elegans nervous system. | Open Access Research Cell-specific microarray profiling experiments reveal a comprehensive picture of gene expression in the C. elegans nervous system Stephen E Von StetinaH Joseph D WatsonH Rebecca M Fox Kellen L Olszewski W Clay Spencer Peter J Roy and David M Miller III Addresses Department of Cell and Developmental Biology Vanderbilt University Nashville TN 37232-8240 USA. Graduate Program in Neuroscience Center for Molecular Neuroscience Vanderbilt University Nashville TN 37232-8548 USA. Department of Cell Biology Johns Hopkins School of Medicine Baltimore MD 21205 USA. Department of Molecular Biology Lewis-Sigler Institute for Integrative Genomics Princeton University 246 Carl Icahn Laboratory Princeton NJ 08544 USA. Department of Medical Genetics and Microbiology Donnelly Centre for Cellular and Biomolecular Research University of Toronto Toronto ON M5S 1A Canada. H These authors contributed equally to this work. Correspondence David M Miller. Email Published 5 July 2007 Genome Biology 2007 8 R135 doi gb-2007-8-7-r135 The electronic version of this article is the complete one and can be found online at http 2007 8 7 R135 Received 16 April 2007 Revised 13 June 2007 Accepted 5 July 2007 2007 Von Stetina et al. licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background With its fully sequenced genome and simple well-defined nervous system the nematode Caenorhabditis elegans offers a unique opportunity to correlate gene expression with neuronal differentiation. The lineal origin cellular morphology and synaptic connectivity of each of the 302 neurons are known. In many instances specific behaviors can be attributed to particular neurons or circuits. Here we .