tailieunhanh - Báo cáo y học: "Genome-wide investigation reveals pathogen-specific and shared signatures in the response of Caenorhabditis elegans to infection"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Critical Care giúp cho các bạn có thêm kiến thức về ngành y học đề tài:Genome-wide investigation reveals pathogen-specific and shared signatures in the response of Caenorhabditis elegans to infection. | Open Access Research Genome-wide investigation reveals pathogen-specific and shared signatures in the response of Caenorhabditis elegans to infection Daniel Wong Daphne Bazopoulou Nathalie Pujol Nektarios Tavernarakis and Jonathan J Ewbank Addresses Centre d lmmunologie de Marseille-Luminy Université de la Méditerranée Case 906 13288 Marseille Cedex 9 France. Institut National de la Santé et de la Recherche Médicale U631 13288 Marseille France. Centre National de la Recherche Scientifique UMR6102 13288 Marseille France. institute of Molecular Biology and Biotechnology Foundation for Research and Technology Heraklion 71110 Crete Greece. Correspondence Jonathan J Ewbank. Email ewbank@ Published 17 September 2007 Genome Biology 2007 8 RI94 doi gb-2007-8-9-rI 94 The electronic version of this article is the complete one and can be found online at http 2007 8 9 RI94 Received 6 June 2007 Revised I4 September 2007 Accepted I7 September 2007 2007 Wong et al. licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background There are striking similarities between the innate immune systems of invertebrates and vertebrates. Caenorhabditis elegans is increasingly used as a model for the study of innate immunity. Evidence is accumulating that C. elegans mounts distinct responses to different pathogens but the true extent of this specificity is unclear. Here we employ direct comparative genomic analyses to explore the nature of the host immune response. Results Using whole-genome microarrays representing 20 334 genes we analyzed the transcriptional response of C. elegans to four bacterial pathogens. Different bacteria provoke pathogen-specific signatures within the host involving differential .