tailieunhanh - Báo cáo y học: " Functional diversification of sonic hedgehog paralog enhancers identified by phylogenomic reconstruction"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Critical Care giúp cho các bạn có thêm kiến thức về ngành y học đề tài: Functional diversification of sonic hedgehog paralog enhancers identified by phylogenomic reconstruction. | Open Access Research Functional diversification of sonic hedgehog paralog enhancers identified by phylogenomic reconstruction Yavor Hadzhiev Michael Lang Raymond Ertzer Axel Meyer Uwe Strahle and Ferenc Muller Addresses laboratory of Developmental Transcription Regulation Institute of Toxicology and Genetics Forschungszentrum Karlsruhe Karlsruhe D-76021 Germany. Laboratory of Developmental Neurobiology and Genetics Institute of Toxicology and Genetics Forschungszentrum Karlsruhe Karlsruhe D-76021 Germany. Department of Zoology and Evolution biology Faculty of Biology University of Konstanz Konstanz D-78457 Germany. Departament de Genètica Universitat de Barcelona Av. Diagonal 645 08028 Barcelona Spain. Correspondence Ferenc Muller. Email Published 8 June 2007 Genome Biology 2007 8 R106 doi gb-2007-8-6-rl 06 The electronic version of this article is the complete one and can be found online at http 2007 8 6 R106 Received 8 January 2007 Revised 9 May 2007 Accepted 8 June 2007 2007 Hadzhiev et al. licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background C s-regulatory modules of developmental genes are targets of evolutionary changes that underlie the morphologic diversity of animals. Little is known about the grammar of interactions between transcription factors and c s-regulatory modules and therefore about the molecular mechanisms that underlie changes in these modules particularly after gene and genome duplications. We investigated the ar-C midline enhancer of son c hedgehog shh orthologs and paralogs from distantly related vertebrate lineages from fish to human including the basal vertebrate Lat mer a menadoens s. Results We demonstrate that the son c hedgehog