tailieunhanh - Báo cáo y học: "Characterization and modeling of the Haemophilus influenzae core and supragenomes based on the complete genomic sequences of Rd and 12 clinical nontypeable strain"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Critical Care giúp cho các bạn có thêm kiến thức về ngành y học đề tài: Characterization and modeling of the Haemophilus influenzae core and supragenomes based on the complete genomic sequences of Rd and 12 clinical nontypeable strains. | Research Open Access Characterization and modeling of the Haemophilus influenzae core and supragenomes based on the complete genomic sequences of Rd and 12 clinical nontypeable strains Justin S Hogg Fen Z Hu Benjamin Janto Robert Boissy Jay Hayes Randy Keefe J Christopher Post and Garth D Ehrlich Addresses Allegheny General Hospital Allegheny-Singer Research Institute Center for Genomic Sciences Pittsburgh Pennsylvania 15212 USA. Joint Carnegie Mellon University - University of Pittsburgh . Program in Computational Biology. 3064 Biomedical Science Tower 3 3501 Fifth Avenue Pittsburgh Pennsylvania 15260 USA. Correspondence Fen Z Hu. Email fhu@. Garth D Ehrlich. Email gehrlich@ Published 5 June 2007 Genome Biology 2007 8 Rl03 doi gb-2007-8-6-rl03 The electronic version of this article is the complete one and can be found online at http 2007 8 6 Rl03 Received 9 February 2007 Revised 17 April 2007 Accepted 5 June 2007 2007 Hogg et al. licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background The distributed genome hypothesis DGH posits that chronic bacterial pathogens utilize polyclonal infection and reassortment of genic characters to ensure persistence in the face of adaptive host defenses. Studies based on random sequencing of multiple strain libraries suggested that free-living bacterial species possess a supragenome that is much larger than the genome of any single bacterium. Results We derived high depth genomic coverage of nine nontypeable Haemophilus influenzae NTHi clinical isolates bringing to I 3 the number of sequenced NTHi genomes. Clustering identified 2 786 genes of which l 46l were common to all strains with each of the remaining l 328 found in a subset .