tailieunhanh - Báo cáo y học: "Modular architecture of protein structures and allosteric communications: potential implications for signaling proteins and regulatory linkages"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Critical Care giúp cho các bạn có thêm kiến thức về ngành y học đề tài: Modular architecture of protein structures and allosteric communications: potential implications for signaling proteins and regulatory linkages. | Open Access Research Modular architecture of protein structures and allosteric communications potential implications for signaling proteins and regulatory linkages Antonio del Sol Marcos J Araúzo-Bravo Dolors Amoros and Ruth Nussinovn Addresses Bioinformatics Research Unit Research and Development Division Fujirebio Inc. Komiya-cho Hachioji-shi Tokyo 192-0031 Japan. Basic Research Program SAIC-Frederick Inc. Center for Cancer Research Nanobiology Program National Cancer Institute Frederick MD 21702 USA. Sackler Institute of Molecular Medicine Department of Human Genetics and Molecular Medicine Tel Aviv University Tel Aviv 69978 Israel. Correspondence Antonio del Sol. Email ao-mesa@ Published 25 May 2007 Genome Biology 2007 8 R92 doi 186 gb-2007-8-5-r92 The electronic version of this article is the complete one and can be found online at http 2007 8 5 R92 Received 10 October 2006 Revised 6 February 2007 Accepted 25 May 2007 2007 del Sol et al. licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background Allosteric communications are vital for cellular signaling. Here we explore a relationship between protein architectural organization and shortcuts in signaling pathways. Results We show that protein domains consist of modules interconnected by residues that mediate signaling through the shortest pathways. These mediating residues tend to be located at the inter-modular boundaries which are more rigid and display a larger number of long-range interactions than intra-modular regions. The inter-modular boundaries contain most of the residues centrally conserved in the protein fold which may be crucial for information transfer between amino acids. Our approach to modular decomposition