tailieunhanh - Báo cáo y học: "Regulatory conservation of protein coding and microRNA genes in vertebrates: lessons from the opossum genome"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Critical Care giúp cho các bạn có thêm kiến thức về ngành y học đề tài: Regulatory conservation of protein coding and microRNA genes in vertebrates: lessons from the opossum genome. | Open Access Research Regulatory conservation of protein coding and microRNA genes in vertebrates lessons from the opossum genome Shaun Mahony David L Corcoran Eleanor Feingold and Panayiotis V Benos Addresses Department of Computational Biology School of Medicine University of Pittsburgh Fifth Avenue Pittsburgh PA 15260 USA. Department of Human Genetics Graduate School of Public Health University of Pittsburgh DeSoto Street Pittsburgh PA 15261 USA. Department of Biostatistics Graduate School of Public Health University of Pittsburgh DeSoto Street Pittsburgh PA 15261 USA. University of Pittsburgh Cancer Institute School of Medicine University of Pittsburgh Centre Avenue Pittsburgh PA 15232 USA. Correspondence Panayiotis V Benos. Email benos@ Published 16 May 2007 Genome Biology 2007 8 R84 doi 186 gb-2007-8-5-r84 The electronic version of this article is the complete one and can be found online at http 2007 8 5 R84 Received 6 November 2006 Revised 29 January 2007 Accepted 16 May 2007 2007 Mahony et al. licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background Being the first noneutherian mammal sequenced Monodelphis domestica opossum offers great potential for enhancing our understanding of the evolutionary processes that take place in mammals. This study focuses on the evolutionary relationships between conservation of noncoding sequences cis-regulatory elements and biologic functions of regulated genes in opossum and eight vertebrate species. Results Analysis of 145 intergenic microRNA and all protein coding genes revealed that the upstream sequences of the former are up to twice as conserved as the latter among mammals except in the first 500 base pairs where the conservation is .