tailieunhanh - Báo cáo khoa học: Malaria ) an overview

Malaria is caused by protozoan parasites of the genusPlasmodiumand is a major cause of mortality and morbidity worldwide. These parasites have a complex life cycle in their mosquito vector and vertebrate hosts. The pri-mary factors contributing to the resurgence of malaria are the appearance of drug-resistant strains of the parasite, the spread of insecticide-resistant strains of the mosquito and the lack of licensed malaria vaccines of proven efficacy. | MINIREVIEW Malaria - an overview Renu Tuteja Malaria Group InternationalCentre for Genetic Engineering and Biotechnology New Delhi India Keywords cerebral malaria erythrocytes malaria life cycle malaria parasite mosquito parasite genome parasite transcriptome pathogenesis Plasmodium falciparum red blood cells Correspondence R. Tuteja Malaria Group International Centre for Genetic Engineering and Biotechnology PO Box 10504 Aruna Asaf Ali Marg New Delhi 110067 India Fax 91 11 26742316 Tel 91 11 26741358 E-mail renu@ Received 30 April 2007 revised 26 June 2007 accepted 19 July 2007 doi Malaria is caused by protozoan parasites of the genus Plasmodium and is a major cause of mortality and morbidity worldwide. These parasites have a complex life cycle in their mosquito vector and vertebrate hosts. The primary factors contributing to the resurgence of malaria are the appearance of drug-resistant strains of the parasite the spread of insecticide-resistant strains of the mosquito and the lack of licensed malaria vaccines of proven efficacy. This minireview includes a summary of the disease the life cycle of the parasite information relating to the genome and proteome of the species lethal to humans Plasmodium falciparum together with other recent developments in the field. The term malaria is derived from the Italian mal aria which means bad air from the early association of the disease with marshy areas. Towards the end of the 19th century Charles Louis Alphonse Laveran a French army surgeon noticed parasites in the blood of a patient suffering from malaria and Dr Ronald Ross a British medical officer in Hyderabad India discovered that mosquitoes transmitted malaria. The Italian professor Giovanni Battista Grassi subsequently showed that human malaria could only be transmitted by Anopheles mosquitoes. Malaria affects a large number of countries and it has been reported that the incidence of the disease in 2004 was between 350 .